Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Y. Aoyama, H. Yamazaki, K. Nishimura, M. Nomura, T. Shigehiro, T. Suzuki, W. Zang, Y. Tatara, H. Ito, Y. Hayashi, Y. Koike, M. Fukumoto, A. Tanaka, Y. Zhang, W. Saika, C. Hasegawa, S. Kasai, Y. Kong, Y. Minakuchi, K. Itoh, M. Yamamoto, S. Toyokuni, A. Toyoda, T. Ikawa, A. Takaori-Kondo, D. Inoue

Blood, vol. 145, 2025, pp. 1149--1163

Association between NF-E2-related factor 2 polymorphism and age-related hearing loss in the general Japanese population from the Iwaki health promotion project

T. Kasai, A. Sasaki, S. Kasai, S. Miura, S. Goto, R. Yotsuyanagi, T. Mikami, Y. Tamada, K. Itoh, A. Matsubara

Acta Otolaryngologica, vol. 145(1), 2025

Dairy consumption has a partial inverse association with systolic blood pressure and hypertension in populations with high salt and low dairy diets: cross-sectional data analysis from the Iwaki Health Promotion Project

D. Kawata, H.M. Ueno, A. Nakano, Y. Tatara, Y. Tamada, T. Mikami, K. Murashita, S. Nakaji, K. Itoh

Hypertens Res, vol. 48, 2025, pp. 1409--1421

Relationship between amino acid transporter activity and radioactive iodine therapy efficacy in differentiated thyroid cancer

A. Kotani, Y. Tatara, R. Sakamoto, A. Wojcik, Y. Mariya, S. Monzen

Oncol Rep, vol. 54, 2025, p. 160

Secretion of specific metabolites and changes in miRNA expression in murine osteoblastic cells exposed in vitro to α‑radiation

S. Monzen, Y. Tatara, M. Chiba, Y. Mariya, A. Wojcik

Int J Mol Med, vol. 56, 2025, p. 161

Cerebrospinal fluid-driven extracellular vesicle as a potential diagnostic biomarker for multiple system atrophy

E. Shibuya, Y. Miki, M.T. Tanaka, T. Ueno, S. Shimoyama, Y. Tatara, H. Nishijima, A. Arai, C. Suzuki, F. Mori, K. Wakabayashi, M. Tomiyama

J Neurol Sci, vol. 478, 2025, p. 123738

Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares

Y. Tatara, H. Yamamoto, K. Terai, R. Matsuta, S. Kasai, Y. Tamada, T. Mikami, K. Murashita, K. Itoh

Metabolomics, vol. 21, 2025, p. 164

Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice

M. Yamaguchi, K.T. Htun, Y. Tatara, Y. Sato, M. Hosoda, S. Kothan, C. Kamimura, O. Inanami, I. Kashiwakura

Sci Rep, vol. 15, 2025, p. 4447

Acute radiation exposure in mice reveals traces of oxidation-mediated modifications in serum albumin

M. Yamaguchi, Y. Tatara, Y. Sato, I. Kashiwakura

PLoS One, vol. 20, 2025, pp. e0330925

Identification of Serum Biomarkers for Early-Stage Knee Osteoarthritis Using Proteomics in a Murine Model of Osteoarthritis

S. Yamauchi, E. Sasaki, Y. Tatara, K. Ishibashi, T. Tsushima, Y. Kimura, E. Tsuda, Y. Ishibashi

Cartilage, 2025, p. 19476035251363443

MEG3 Promoter Methylation and F11 Receptor (F11R) Overexpression Define a High-Risk Subtype of Diabetic Pancreatic Cancer

K. Yamazaki, H. Mizukami, T. Yamada, Y. Hara, H. Tamba, Y. Tatara, Z. Wang, A. Itaya, H. Kushibiki, M. Ryuzaki, T. Sasaki, H. Ruike, S. Ogasawara, Y. Tu, K. Ishido, K. Itoh, K. Hakamada

Modern Pathology, vol. 39, 2025, p. 100953

Graphical model analysis of subjective well-being and various factors in Japanese adults from the Iwaki cross-sectional study

S. Sakai, A. Onoda, E. Hasegawa, I. Kawanishi, G. Ikeda, K. Murashita, K. Itoh, Y. Tamada, T. Mikami, S. Nakaji, C. Furuta

Sci Rep, vol. 15, 2025 Apr, p. 14570

Role of calpain-5 in cerebral ischemia and reperfusion injury

Y. Chukai, G. Ito, Y. Miki, K. Wakabayashi, K. Itoh, E. Sugano, H. Tomita, T. Fukuda, T. Ozaki

Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1868, 2024, p. 130506

Author Correction: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

S. Dayalan Naidu, A. Muramatsu, R. Saito, S. Asami, T. Honda, T. Hosoya, K. Itoh, M. Yamamoto, T. Suzuki, A. T. Dinkova-Kostova

Scientific Reports, vol. 14, 2024, p. 4774

Association between sex hormones and erectile dysfunction in men without hypoandrogenism

N. Fujita, T. Okamoto, H. Yamamoto, T. Yoneyama, Y. Hashimoto, T. Mikami, K. Itoh, C. Ohyama, S. Hatakeyama

Scientific Reports, vol. 14, 2024, p. 13433

Overexpression of carbonyl reductase 1 in ovarian cancer cells suppresses proliferation and activates the eIF2 signaling pathway

Y. Kadonosawa, M. Yokoyama, Y. Tatara, T. Fujita, Y. Yokoyama

Oncology Letters, vol. 28, 2024, p. 359

Characteristics of sphingomyelin metabolism in the MCF7 and BT474 radiotherapy‑resistant HER2‑positive breast cancer cell lines

M. Kikuchi, S. Monzen, M. Horikoshi, S. Tsuda, Y. Tatara, A. Wojcik, Y. Mariya

Oncology Letters, vol. 28, 2024, p. 471

Dairy consumption, bone turnover biomarkers, and osteo sono assessment index in Japanese adults

A. Nakano, H. M. Ueno, D. Kawata, Y. Tatara, Y. Tamada, T. Mikami, K. Murashita, S. Nakaji, K. Itoh

Bone Reports, vol. 21, 2024, p. 101770

Exploring predictive molecules of acute adverse events in response to volumetric‑modulated arc therapy for prostate cancer using urinary metabolites

H. Obara, Y. Tatara, S. Monzen, S. Murakami, H. Yamamoto, N. Kimura, M. Suzuki, F. Komai, M. Narita, Y. Hatayama

Molecular and Clinical Oncology, vol. 21, 2024, p. 62

Emerging Role of GCN1 in Disease and Homeostasis

Y. Tatara, S. Kasai, D. Kokubu, T. Tsujita, J. Mimura, K. Itoh

International Journal of Molecular Sciences, vol. 25, 2024, p. 2998

未病制御におけるNrf2酸化ストレス応答機構の役割とその分子機構 未病期に活躍するストレス応答機構について考察する

伊東 健, 葛西 秋宅, 多田羅 洋太

化学と生物, vol. 62, 2024, pp. 145--153

Nrf2 induction potency of plant-derived compounds determined using an antioxidant response element luciferase reporter and conventional NAD(P)H-quinone acceptor oxidoreductase 1 activity assay

E. Tamaru, D. Kokubu, Y. Ushida, K. Itoh

BMC Research Notes, vol. 17, 2024 Dec, p. 373

Characteristics of sphingomyelin metabolism in the MCF7 and BT474 radiotherapy‑resistant HER2‑positive breast cancer cell lines

Megumi Kikuchi, Satoru Monzen, Mai Horikoshi, Shuri Tsuda, Yota Tatara, Andrzej Wojcik, Yasushi Mariya

Oncol Lett, vol. 28(4), 2024 Oct, p. 471

Intranasal administration of trehalose reduces α-synuclein oligomers and accelerates α-synuclein aggregation

M. Tanaka, Y. Miki, F. Mori, T. Kon, T. Furukawa, S. Shimoyama, Y. Tatara, T. Ozaki, C. Bettencourt, T.s T. Warner, K. Wakabayashi

Brain Communications, vol. 6, 2024 Aug, pp. fcae193

Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery

H. Fujita, T. Wakiya, Y. Tatara, K. Ishido, Y. Sakamoto, N. Kimura, H. Morohashi, T. Miura, T. Muroya, H. Akasaka, H. Yokoyama, T. Kanda, S. Kubota, A. Ichisawa, K. Ogasawara, D. Kuwata, Y. Takahashi, A. Nakamura, K. Yamazaki, T. Yamada, R. Matsuyama, M. Kanou, K. Yamana, K. Itoh, K. Hakamada

Scientific Reports, vol. 14, 2024 Jul, p. 16557

Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction

N. Fujita, M. Ishida, T. Iwane, H. Suganuma, M. Matsumoto, S. Hatakeyama, T. Yoneyama, Y. Hashimoto, T. Mikami, K. Itoh, C. Ohyama

World Journal of Men's Health, vol. 41, 2023, pp. 701--711

Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study

N. Fuke, T. Yamashita, S. Shimizu, M. Matsumoto, K. Sawada, S. Jung, I. Tokuda, M. Misawa, S. Suzuki, Y. Ushida, T. Mikami, K. Itoh, H. Suganuma

Metabolites, vol. 13, 2023, p. 250

Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation

A. Inose-Maruyama, S. Kasai, K. Itoh

Methods in Molecular Biology, vol. 2651, Humana Press, 2023, pp. 157--166

Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity

G. Ito, Y. Tatara, K. Itoh, M. Yamada, T. Yamashita, K. Sakamoto, T. Nozaki, K. Ishida, Y. Wake, T. Kaneko, T. Fukuda, E. Sugano, H. Tomita, T. Ozaki

BBA Advances, vol. 3, 2023, p. 100092

Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response

S. Kasai, D. Kokubu, H. Mizukami, K. Itoh

Biomolecules, vol. 13, 2023, p. 1544

Annual Stability of the Plasma Abeta40/42 Ratio and Associated Factors

T. Kawarabayashi, N. Nakahata, K. Itoh, K. Ihara, S. Nakaji, Y. Ikeda, M. Takatama, M. Shoji

Annals of Clinical and Translational Neurology, vol. 10, 2023, pp. 879--891

Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver

Y. Kimura, F. A. Ekuban, C. Zong, S. Sugie, X. Zhang, K. Itoh, M. Yamamoto, S. Ichihara, S. Ohsako, G. Ichihara

Toxicological Sciences, vol. 195, 2023, pp. 28--41

Exploration of Malignant Characteristics in Neoadjuvant Chemotherapy-Resistant Rectal Cancer, Focusing on Extramural Lesions

S. Kubota, T. Miura, T. Wakiya, T. Yoshizawa, S. Goto, H. Morohashi, Y. Sakamoto, Y. Tatara, H. Kijima, K. Hakamada

Annals of Surgical Oncology, vol. 30, 2023, pp. 7612--7623

Purification and characterization of hyaluronate lyases produced by two types of bacteria

S. Li, X. Wang, Y. Tatara, S. Hamada, T. Kozeki, K. Kojima, T. Yoshida

Agricultural Biotechnology, vol. 12, 2023, pp. 99--104

Individual Health-Disease Phase Diagrams for Disease Prevention Based on Machine Learning

K. Nakamura, E. Uchino, N. Sato, A. Araki, K. Terayama, R. Kojima, K. Murashita, K. Itoh, T. Mikami, Y. Tamada, Y. Okuno

Journal of Biomedical Informatics, vol. 144, 2023, p. 104448

Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer's Disease

T. Nakamura, T. Kawarabayashi, T. Ueda, S. Shimomura, M. Hoshino, K. Itoh, K. Ihara, S. Nakaji, M. Takatama, Y. Ikeda, M. Shoji

Journal of Alzheimer's Disease, vol. 93, 2023, pp. 333--348

Does the Protective Effect of Zinc on Telomere Length Depend on the Presence of Hypertension or Type 2 Diabetes? Results from the Iwaki Health Promotion Project, Japan

M. Sato, K. M. Wai, K. Itoh, Y. Yang, Y. Uchikawa, Y. Ito, S. Nakaji, K. Ihara

Nutrients, vol. 15, 2023, p. 4373

Proteomics and secreted lipidomics of mouse-derived bone marrow cells exposed to a lethal level of ionizing radiation

Y. Tatara, S. Monzen

Scientific Reports, vol. 13, 2023, p. 8802

Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment

Y. Tatara, H. Yamazaki, F. Katsuoka, M. Chiba, D. Saigusa, S. Kasai, T. Nakamura, J. Inoue, Y. Aoki, M. Shoji, I. N. Motoike, Y. Tamada, K. Hashizume, K. Kinoshita, K. Murashita, S. Nakaji, M. Yamamoto, K. Itoh

Current Research in Translational Medicine, vol. 71, 2023, p. 103367

Definition of a Dietary Pattern Expressing the Intake of Vegetables and Fruits and Its Association with Intestinal Microbiota

T. Yamauchi, N. Koyama, A. Hirai, H. Suganuma, S. Suzuki, K. Murashita, T. Mikami, Y. Tamada, N. Sato, S. Imoto, K. Itoh, S. Nakaji

Nutrients, vol. 15, 2023, p. 2104

Development of transgenic mice overexpressing mouse carbonyl reductase 1

M. Yokoyama, T. Fujita, Y. Kadonosawa, Y. Tatara, D. Motooka, M. Ikawa, H. Fujii, Y. Yokoyama

Molecular Biology Reports, vol. 50, 2023, pp. 531--540

ストレス応答転写因子Nrf2とATF4を中心とした未病期における動的な恒常性維持機構

伊東 健, 長谷川 和輝, 葛西 秋宅

Biomedical Gerontology, vol. 47, 2023, pp. 15--20

生体内環境調節因子によるミトコンドリア恒常性維持機構

伊東 健, 葛西 秋宅

実験医学, vol. 41(5), 2023, pp. 699-705

Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases

H. Iwamura, K. Mizuno, S. Akamatsu, S. Hatakeyama, Y. Tobisawa, S. Narita, T. Narita, S. Yamashita, S. Kawamura, T. Sakurai, N. Fujita, H. Kodama, D. Noro, I. Kakizaki, S. Nakaji, K. Itoh, N. Tsuchiya, A. Ito, T. Habuchi, C. Ohyama, T. Yoneyama

Cancer Science, vol. 113, 2022, pp. 2434--2445

Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage

J. Liu, S. Kasai, Y. Tatara, H. Yamazaki, J. Mimura, S. Mizuno, F. Sugiyama, S. Takahashi, T. Sato, T. Ozaki, K. Tanji, K. Wakabayashi, H. Maeda, H. Mizukami, Y. Shinkai, Y. Kumagai, H. Tomita, K. Itoh

International Journal of Molecular Sciences, vol. 23, 2022, p. 3201

Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility

R. Sehsah, W. Wu, S. Ichihara, N. Hashimoto, C. Zong, K. Yamazaki, H. Sato, K. Itoh, M. Yamamoto, A. A. Elsayed, S. El-Bestar, E. Kamel, G. Ichihara

Toxicology Letters, vol. 370, 2022, pp. 24--34

Sulforaphane increases mitochondrial biogenesis-related gene expression in the hippocampus and suppresses age-related cognitive decline in mice

S. Shimizu, S. Kasai, H. Yamazaki, Y. Tatara, J. Mimura, M. J. Engler, K. Tanji, Y. Nikaido, T. Inoue, H. Suganuma, K. Wakabayashi, K. Itoh

International Journal of Molecular Sciences, vol. 23, 2022, p. 8433

Oxidative Modification Status of Human Serum Albumin Caused by Chronic Low-Dose Radiation Exposure in Mamuju, Sulawesi, Indonesia

Masaru Yamaguchi, Yota Tatara, Eka Djatnika Nugraha, Yuki Tamakuma, Yoshiaki Sato, Tomisato Miura, Masahiro Hosoda, Shinji Yoshinaga, Mukh Syaifudin, Shinji Tokonami, Ikuo Kashiwakura

Antioxidants (Basel), vol. 11(12), Basel, Switzerland, 2022 Dec, p. 2384

Heterogeneity of metabolic adaptive capacity affects the prognosis among pancreatic ductal adenocarcinomas

Taishu Kanda, Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hiroaki Fujita, Tadashi Yoshizawa, Shintaro Goto, Yota Tatara, Hiroshi Kijima, Kenichi Hakamada

J Gastroenterol, vol. 57(10), 2022 Oct, pp. 798--811

Serum Proteomic and Oxidative Modification Profiling in Mice Exposed to Total Body X-Irradiation

Masaru Yamaguchi, Yota Tatara, Eka Djatnika Nugraha, Yoshiaki Sato, Tomisato Miura, Masahiro Hosoda, Mukh Syaifudin, Shinji Tokonami, Ikuo Kashiwakura

Antioxidants (Basel), vol. 11(9), Basel, Switzerland, 2022 Aug, p. 1710

Association of Mitochondrial DNA Haplogroup and Hearing Impairment with Aging in Japanese General Population of the Iwaki Health Promotion Project

S. Miura, A. Sasaki, S. Kasai, T. Sugawara, Y. Maeda, S. Goto, T. Kasai, N. Shimizume, S. Jung, T. Iwane, K. Itoh, A. Matsubara

Journal of Human Genetics, vol. 67, 2022 Jun, pp. 369--751

Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population

T. Hasegawa, M. Kakuta, R. Yamaguchi, N. Sato, T. Mikami, K. Murashita, S. Nakaji, K. Itoh, S. Imoto

Scientific Reports, vol. 12, 2022 May, p. 7628

Detection of biological responses to low-dose radiation in humans

Masaru Yamaguchi, Yota Tatara, Eka Djatnika Nugraha, Dwi Ramadhani, Yuki Tamakuma, Yoshiaki Sato, Tomisato Miura, Masahiro Hosoda, Shinji Yoshinaga, Mukh Syaifudin, Ikuo Kashiwakura, Shinji Tokonami

Free Radic Biol Med, vol. 184, 2022 May, pp. 196--207

Characterization of mitochondrial calpain-5

Y. Chukai, T. Iwamoto, K. Itoh, H. Tomita, T. Ozaki

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1868, 2021, p. 118989

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

M.-F. Dorion, M. Mulumba, S. Kasai, K. Itoh, W. D. Lubell, H. Ong

Oxidative Medicine and Cellular Longevity, vol. 2021, 2021, p. 6691402

Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice

F. A. Ekuban, C. Zong, M. Takikawa, K. Morikawa, T. Sakurai, S. Ichihara, K. Itoh, M. Yamamoto, S. Ohsako, G. Ichihara

Toxicology, vol. 456, 2021, p. 152785

Association between Serum Concentration of Carotenoid and Visceral Fat

M. Matsumoto, H. Suganuma, N. Ozato, S. Shimizu, M. Katashima, Y. Katsuragi, T. Mikami, K. Itoh, S. Nakaji

Nutrients, vol. 13, 2021, p. 912

Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project

N. Nakahata, T. Nakamura, T. Kawarabayashi, Y. Seino, S. Ichii, Y. Ikeda, M. Amari, M. Takatama, K. Murashita, K. Ihara, K. Itoh, S. Nakaji, M. Shoji

Journal of Alzheimer's Disease, vol. 84, 2021, pp. 1233--1245

Health improvement framework for actionable treatment planning using a surrogate Bayesian model

K. Nakamura, R. Kojima, E. Uchino, K. Ono, M. Yanagita, K. Murashita, K. Itoh, S. Nakaji, Y. Okuno

Nature Communications, vol. 12, 2021, p. 3088

Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study

H. Yamamoto, M. Suzuki, R. Matsuta, K. Sasaki, M. I. Kang, K. Kami, Y. Tatara, K. Itoh, S. Nakaji

Metabolites, vol. 11, 2021, p. 314

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction

A. Zhang, T. Suzuki, S. Adachi, E. Naganuma, N. Suzuki, T. Hosoya, K. Itoh, M. B. Sporn, M. Yamamoto

Molecular and Cellular Biology, 2021

Telomere Length and Arterial Stiffness Reflected by Brachial-Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

K. M. Wai, S. Kaori, K. Itoh, O. Shinya, Y. Uchikawa, S. Hayashi, A. Shiraki, K. Murashita, S. Nakaji, K. Ihara

Journal of Personalized Medicine, vol. 11, 2021 Dec, p. 1278

Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer

Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Tadashi Yoshizawa, Satoko Morohashi, Hiroaki Fujita, Taishu Kanda, Yota Tatara, Junji Saruwatari, Hiroshi Kijima, Kenichi Hakamada

Sci Rep, vol. 11, 2021 Oct, p. 21197

Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis

M. Sugawara, T. Abe, S. Kasai, K. Itoh, T. Ozaki

Biochemical and Biophysical Reports, vol. 27, 2021 Aug, p. 101101

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis

M. J. Engler, J. Mimura, S. Yamazaki, K. Itoh

FEBS Open Bio, vol. 10, 2020, pp. 2771--2779

Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan

Y. Maeda, A. Sasaki, S. Kasai, S. Goto, S. Nishio, K. Sawada, I. Tokuda, K. Itoh, S. Usami, A. Matsubara

Human Genome Variation, vol. 7, 2020, p. 27

Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation

H. Yamazaki, K. Itoh

Progress in Inflammation Research, H. Deng, Nrf2 and its Modulation in Inflammation, vol. 85, Springer, Cham, 2020

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

H. Yamazaki, S. Kasai, J. Mimura, P. Ye, A. Inose-Maruyama, K. Tanji, K. Wakabayashi, S. Mizuno, F. Sugiyama, S. Takahashi, T. Sato, T. Ozaki, D. R. Cavener, M. Yamamoto, K. Itoh

PLoS Genetics, vol. 16, 2020, pp. e1008693

Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice

Y. Yokono, K. Hanada, M. Narita, Y. Tatara, Y. Kawamura, N. Miura, K. Kitayama, M. Nakata, M. Nozaka, T. Kato, N. Kodo, M. Tsushima, Y. Toyama, K. Itoh, H. Tomita

Journal of the American Heart Association, 2020, pp. e015616

ファイトケミカルによるKeap1-Nrf2経路の活性化

三村純正, 伊東健

実験医学, vol. 38, 2020, pp. 99--105

慢性腎臓病におけるNrf2-Keap1経路の役割-CKD治療薬としての期待

伊東健, Jun Liu, 葛西秋宅

臨床透析, vol. 36, 2020, pp. 35--41

ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発

葛西秋宅, 清水直, 多田羅洋太, 三村純正, 伊東健

BIO Clinica, vol. 35, 2020, pp. 60--64

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging

S. Shimizu, J. Mimura, T. Hasegawa, E. Shimizu, S. Imoto, M. Tsushima, S. Kasai, H. Yamazaki, Y. Ushida, H. Suganuma, H. Tomita, M. Yamamoto, S. Nakaji, K. Itoh

PLoS One, vol. 15, 2020 Aug, pp. e0236834

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

M. Matsumoto, N. Waki, H. Suganuma, I. Takahashi, S. Kurauchi, K. Sawada, I. Tokuda, M. Misawa, M. Ando, K. Itoh, K. Ihara, S. Nakaji

Nutrients, vol. 12, 2020 Jul, pp. E2310

Emerging Evidence for Crosstalk Between Nrf2 and Mitochondria in Physiological Homeostasis and in Heart Disease

M. Tsushima, J. Liu, W. Hirao, H. Yamazaki, H. Tomita, K. Itoh

Archives of Pharmacal Research, vol. 43, 2020 Mar, pp. 286--296

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

S. Kasai, S. Shimizu, Y. Tatara, J. Mimura, K. Itoh

Biomolecules, vol. 10, 2020 Feb, p. 320

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

S. Kasai, H. Yamazaki, K. Tanji, Mate Janos Engler, T. Matsumiya, K. Itoh

Journal of Clinical Biochemistry and Nutrition, vol. 64, 2019, pp. 1--12

Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes

J. Mimura, A. Inose-Maruyama, S. Taniuchi, K. Kosaka, H. Yoshida, H. Yamazaki, S. Kasai, N. Harada, R. J. Kaufman, S. Oyadomari, K. Itoh

International Journal of Molecular Sciences, vol. 20, 2019, p. 1706

Concomitant Nrf2- and ATF4-Activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes

J. Mimura, A. Inose-Maruyama, S. Taniuchi, K. Kosaka, H. Yoshida, H. Yamazaki, S. Kasai, N. Harada, R. J. Kaufman, S. Oyadomari, K. Itoh

International Journal of Molecular Sciences, vol. 20, 2019, p. 1706

Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles

R. Sehsah, W. Wu, S. Ichihara, N. Hashimoto, Y. Hasegawa, C. Zong, K. Itoh, M. Yamamoto, A. A. Elsayed, K. E. El-Bestar, G. Ichihara

Particle and Fibre Toxicology, vol. 16, 2019, p. 47

Increase of Tumor Infiltrating γδT-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone

A. Suto, D. Kudo, E. Yoshida, H. Nagase, S. Suto, J. Mimura, K. Itoh, K. Hakamada

Pancreas, vol. 48, 2019, pp. 292--298

Nrf2とATF4の相互作用に着目した疾患予防・アンチエイジング法の開発

伊東健, 平尾航, 加藤恭丈, 三村純正, 葛西秋宅

Medical Science Digest, vol. 45, 2019, pp. 56--59

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

S. Dayalan Naidu, A. Muramatsu, R. Saito, S. Asami, T. Honda, T. Hosoya, K. Itoh, M. Yamamoto, T. Suzuki, A. T. Dinkova-Kostova

Scientific Reports, vol. 8, 2018, p. 8037

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators

S. Dayalan Naidu, A. Muramatsu, R. Saito, S. Asami, T. Honda, T. Hosoya, K. Itoh, M. Yamamoto, T. Suzuki, A. T. Dinkova-Kostova

Scientific Reports, vol. 8, 2018, p. 8037

Emerging Regulatory Role of Nrf2 in Iron, Heme and Hemoglobin Metabolism in Physiology and Disease

S. Kasai, J. Mimura, T. Ozaki, K. Itoh

Frontiers in Veterinary Science, vol. 5, 2018, p. 242

Emerging regulatory role of Nrf2 in iron, heme and hemoglobin metabolism in physiology and disease

S. Kasai, J. Mimura, T. Ozaki, K. Itoh

Frontiers in Veterinary Science, vol. 5, 2018, p. 242

Aging and APOE-ε4 are determinative factors of plasma A β 42 levels

T. Nakamura, T. Kawarabayashi, Y. Seino, M. Hirohata, N. Nakahara, S. Narita, K. Itoh, S. Nakaji, M. Shoji

Annals of Clinical and Translational Neurology, vol. 5, 2018, pp. 1184--1191

Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2

S. Kasai, M. J. E. Richardson, S. Torii, K. Yasumoto, H. Shima, K. Igarashi, K. Itoh, K. Sogawa, K. Murayama

FEBS Journal, vol. 284, 2017, pp. 4115--4127

Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis

E. Sakai, M. Morita, M. Ohuchi, M. A. Kido, Y. Fukuma, K. Nishishita, K. Okamoto, K. Itoh, M. Yamamoto, T. Tsukuba

FASEB Journal, vol. 31, 2017, pp. 4011--4022

Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin K

Y. Tatara, S. Suto, K. Itoh

Glycobiology, vol. 27, 2017, pp. 1089--1098

Nrf2システムによる生体防御応答

三村純正, 伊東健

臨床免疫・アレルギー科, vol. 67, 2017, pp. 642--648

Nrf2の抗老化因子としての役割

山嵜博未, Mate Janos Engler, 伊東健

第37回総会シンポジウム3「老化と循環制御」, 2017, pp. 21--33

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects in combination with quinone-containing compounds and anti-microtubule drugs

P. Y. Liu, N. Sokolowski, S. T. Guo, F. Siddiqi, B. Atmadibrata, T. J. Telfer, Y. Sun, L. Zhang, D. Yu, J. McCarroll, B. Liu, R. H. Yang, X. Y. Guo, A. E. Tee, K. Itoh, J. Wang, M. Kavallaris, M. Haber, M. D. Norris, B. B. Cheung, J. A. Byrne, D. S. Ziegler, G. M. Marshall, M. E. Dinger, R. Codd, X. D. Zhang, T. Liu

Oncotarget, vol. 7, 2016, pp. 79217--79232

The role of NUB1 in α-synuclein degradation in Lewy body disease model mice

K. Tanji, Y. Miki, A. Maruyama, F. Mori, J. Mimura, K. Itoh, T. Kamitani, K. Wakabayashi

Biochemical and Biophysical Research Communications, vol. 470, 2016, pp. 635--642

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases

Junsei Mimura, Ken Itoh

Free Radic Biol Med, vol. 88, 2015 Nov, pp. 221--232

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease

Kunikazu Tanji, Yasuo Miki, Atsushi Maruyama, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Koichi Wakabayashi

Biochem Biophys Res Commun, vol. 465, 2015 Oct, pp. 746--752

p62 Deficiency Enhances α-Synuclein Pathology in Mice

Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi

Brain Pathol, vol. 25, Zurich, Switzerland, 2015 Sep, pp. 552--564

Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells

Pengfei Meng, Hidemi Yoshida, Kunikazu Tanji, Tomoh Matsumiya, Fei Xing, Ryo Hayakari, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Shogo Kawaguchi, Tadaatsu Imaizumi

Neurosci Res, vol. 94, 2015 May, pp. 1--9

Role of Nrf2 in the pathogenesis of atherosclerosis

Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh

Pathol Int, vol. 65, 2015 May, pp. 210--219

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

Ken Itoh, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, Taku Ozaki

J Clin Biochem Nutr, vol. 56, 2015 Mar, pp. 91--97

Role of the keap1-nrf2 pathway in protection against ionizing radiation

A. Maruyama, K. Itoh

2015 Jan, pp. 115--133

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding

Atsushi Maruyama, Junsei Mimura, Ken Itoh

Nucleic Acids Res, vol. 42, 2014 Dec, pp. 13599--13614

Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition

Peng Ye, Junsei Mimura, Tomomi Okada, Hideyo Sato, Tao Liu, Atsushi Maruyama, Chikara Ohyama, Ken Itoh

Mol Cell Biol, vol. 34, 2014 Sep, pp. 3421--3434

Phosphorylation of serine 349 of p62 in Alzheimer's disease brain

Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta Neuropathol Commun, vol. 2, 2014 May, p. 50

Carbocisteine reduces virus-induced pulmonary inflammation in mice exposed to cigarette smoke

Yuichi Yageta, Yukio Ishii, Yuko Morishima, Satoshi Ano, Shigeo Ohtsuka, Masashi Matsuyama, Kaoru Takeuchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa

Am J Respir Cell Mol Biol, vol. 50, 2014 May, pp. 963--973

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells

Hidemi Yoshida, Pengfei Meng, Tomoh Matsumiya, Kunikazu Tanji, Ryo Hayakari, Fei Xing, Liang Wang, Kazushi Tsuruga, Hiroshi Tanaka, Junsei Mimura, Kunio Kosaka, Ken Itoh, Ippei Takahashi, Tadaatsu Imaizumi

Neurosci Res, vol. 79, 2014 Feb, pp. 83--93

Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene

Yukari Okita, Atsushi Kamoshida, Hiroyuki Suzuki, Ken Itoh, Hozumi Motohashi, Kazuhiko Igarashi, Masayuki Yamamoto, Tomohiro Ogami, Daizo Koinuma, Mitsuyasu Kato

J Biol Chem, vol. 288, 2013 Jul, pp. 20658--20667

Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter

Atsushi Maruyama, Junsei Mimura, Nobuhiko Harada, Ken Itoh

Nucleic Acids Res, vol. 41, 2013 May, pp. 5223--5234

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells

Pengfei Meng, Hidemi Yoshida, Tomoh Matsumiya, Tadaatsu Imaizumi, Kunikazu Tanji, Fei Xing, Ryo Hayakari, Junichi Dempoya, Tetsuya Tatsuta, Tomomi Aizawa-Yashiro, Junsei Mimura, Kunio Kosaka, Ken Itoh, Kei Satoh

Neurosci Res, vol. 75, 2013 Feb, pp. 94--102

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases

Kunikazu Tanji, Atsushi Maruyama, Saori Odagiri, Fumiaki Mori, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

J Neuropathol Exp Neurol, vol. 72, 2013 Jan, pp. 18--28

細胞の酸化ストレス耐性に関わるシグナル伝達系

伊東 健, 蝦名 真行

化学と生物, vol. 50, 丸善出版, 2012, pp. 423--429

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

Nobuhiko Harada, Koichi Ito, Tomonori Hosoya, Junsei Mimura, Atsushi Maruyama, Noriko Noguchi, Ken-ichi Yagami, Naoki Morito, Satoru Takahashi, Jon M. Maher, Masayuki Yamamoto, Ken Itoh

Free Radic Biol Med, vol. 53, 2012 Dec, pp. 2256--2262

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

T. Yamadori, Y. Ishii, S. Homma, Y. Morishima, K. Kurishima, K. Itoh, M. Yamamoto, Y. Minami, M. Noguchi, N. Hizawa

Oncogene, vol. 31, 2012 Nov, pp. 4768--4777

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis

Kosuke Okada, Eiji Warabi, Hirokazu Sugimoto, Masaki Horie, Katsutoshi Tokushige, Tetsuya Ueda, Nobuhiko Harada, Keiko Taguchi, Etsuko Hashimoto, Ken Itoh, Tetsuro Ishii, Hirotoshi Utsunomiya, Masayuki Yamamoto, Junichi Shoda

J Gastroenterol, vol. 47, 2012 Aug, pp. 924--935

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda, Yasuo Saijo

BMC Cancer, vol. 12, 2012 Feb, p. 66

Nrf2/Keap1酸化ストレス応答系

伊東 健

日本薬理学雑誌, vol. 138(1), pp. 41-42

Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease

Kunikazu Tanji, Fumiaki Mori, Katsumi Kito, Akiyoshi Kakita, Junsei Mimura, Ken Itoh, Hitoshi Takahashi, Tetsu Kamitani, Koichi Wakabayashi

J Neuropathol Exp Neurol, vol. 70, 2011 Oct, pp. 879--889

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes

Junsei Mimura, Kunio Kosaka, Atsushi Maruyama, Takumi Satoh, Nobuhiko Harada, Hidemi Yoshida, Kei Satoh, Masayuki Yamamoto, Ken Itoh

J Biochem, vol. 150, 2011 Aug, pp. 209--217

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Atsushi Maruyama, Keizo Nishikawa, Yukie Kawatani, Junsei Mimura, Tomonori Hosoya, Nobuhiko Harada, Masayuki Yamamato, Ken Itoh

Biochem J, vol. 436, 2011 Jun, pp. 387--397

Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice

Yuichi Yageta, Yukio Ishii, Yuko Morishima, Hironori Masuko, Satoshi Ano, Tadahiro Yamadori, Ken Itoh, Kaoru Takeuchi, Masayuki Yamamoto, Nobuyuki Hizawa

J Virol, vol. 85, 2011 May, pp. 4679--4690

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

Nobuhiko Harada, Masaya Kanayama, Atsushi Maruyama, Aruto Yoshida, Kyoko Tazumi, Tomonori Hosoya, Junsei Mimura, Tsutomu Toki, Jonathan M. Maher, Masayuki Yamamoto, Ken Itoh

Arch Biochem Biophys, vol. 508, 2011 Apr, pp. 101--109

Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

Yosuke Hirotsu, Fumiki Katsuoka, Ken Itoh, Masayuki Yamamoto

Genes Cells, vol. 16, 2011 Apr, pp. 406--415

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation

Hidemi Yoshida, Junsei Mimura, Tadaatsu Imaizumi, Tomoh Matsumiya, Akira Ishikawa, Norifumi Metoki, Kunikazu Tanji, Ken Ota, Ryo Hayakari, Kunio Kosaka, Ken Itoh, Kei Satoh

Neurosci Res, vol. 69, 2011 Apr, pp. 291--298

Role of Nrf2 in the neurotrophic action of the electrophiles

Itoh K, Kosaka K, Mimura J, Satoh T

Hirosaki Med J, vol. 61, 2010, pp. S63-S69

Keap1/Nrf2酸化ストレス経路による血管内皮細胞保護作用

伊東 健, 原田 伸彦

Heart View, vol. 14, 2010, pp. 1092-1098

Discovery of the negative regulator of Nrf2, Keap1: a historical overview

Ken Itoh, Junsei Mimura, Masayuki Yamamoto

Antioxid Redox Signal, vol. 13, 2010 Dec, pp. 1665--1678

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang, Heather E. Kleiner-Hancock

BMC Cancer, vol. 10, 2010 Oct, p. 540

p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina

Reiichi Murakami, Tomohiro Osanai, Hirofumi Tomita, Satoko Sasaki, Atsushi Maruyama, Ken Itoh, Yoshimi Homma, Ken Okumura

Arterioscler Thromb Vasc Biol, vol. 30, 2010 Oct, pp. 1968--1975

Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells

Kengo Kato, Kenji Takahashi, Satoru Monzen, Hiroyuki Yamamoto, Atsushi Maruyama, Ken Itoh, Ikuo Kashiwakura

Radiat Res, vol. 174, 2010 Aug, pp. 177--184

Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload

Tomoyuki Shirase, Kiyoshi Mori, Yasumasa Okazaki, Ken Itoh, Masayuki Yamamoto, Mitsuaki Tabuchi, Fumio Kishi, Li Jiang, Shinya Akatsuka, Kazuwa Nakao, Shinya Toyokuni

Am J Pathol, vol. 177, 2010 Aug, pp. 677--685

Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

Kunikazu Tanji, Fumiaki Mori, Junsei Mimura, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi

Acta Neuropathol, vol. 120, 2010 Aug, pp. 145--154

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity

Fang Liu, Sahoko Ichihara, William M. Valentine, Ken Itoh, Masayuki Yamamoto, Sahabudeen Sheik Mohideen, Junzoh Kitoh, Gaku Ichihara

Toxicol Sci, vol. 115, 2010 Jun, pp. 596--606

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice

Katsuyuki Iida, Junsei Mimura, Ken Itoh, Chikara Ohyama, Yoshiaki Fujii-Kuriyama, Toru Shimazui, Hideyuki Akaza, Masayuki Yamamoto

J Biochem, vol. 147, 2010 Mar, pp. 353--360

Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

Norihiro Kikuchi, Yukio Ishii, Yuko Morishima, Yuichi Yageta, Norihiro Haraguchi, Ken Itoh, Masayuki Yamamoto, Nobuyuki Hizawa

Respir Res, vol. 11, 2010 Mar, p. 31

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

Kunio Kosaka, Junsei Mimura, Ken Itoh, Takumi Satoh, Yosuke Shimojo, Chieko Kitajima, Atsushi Maruyama, Masayuki Yamamoto, Takuji Shirasawa

J Biochem, vol. 147, 2010 Jan, pp. 73--81

Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1

Tomohisa Takagi, Yuji Naito, Hitomi Okada, Takeshi Ishii, Katsura Mizushima, Satomi Akagiri, Satoko Adachi, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Ken Itoh, Masayuki Yamamoto, Hirofumi Matsui, Toshikazu Yoshikawa

J Pharmacol Exp Ther, vol. 331, 2009 Oct, pp. 255--264

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin

Shintarou Kimura, Eiji Warabi, Toru Yanagawa, Dongmei Ma, Ken Itoh, Yoshiyuki Ishii, Yasuhiro Kawachi, Tetsuro Ishii

Biochem Biophys Res Commun, vol. 387, 2009 Sep, pp. 109--114

Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells

Satoru Monzen, Kenji Takahashi, Hironori Yoshino, Kiyomi Kasai-Eguchi, Yoshinao Abe, Atsushi Maruyama, Ken Itoh, Ikuo Kashiwakura

J Radiat Res, vol. 50, 2009 Sep, pp. 477--486

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

Larry G. Higgins, Michael O. Kelleher, Ian M. Eggleston, Ken Itoh, Masayuki Yamamoto, John D. Hayes

Toxicol Appl Pharmacol, vol. 237, 2009 Jun, pp. 267--280

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

Shinsuke Homma, Yukio Ishii, Yuko Morishima, Tadahiro Yamadori, Yosuke Matsuno, Norihiro Haraguchi, Norihiro Kikuchi, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa, Ken Itoh, Masayuki Yamamoto

Clin Cancer Res, vol. 15, 2009 May, pp. 3423--3432

Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice

Misty Prince, Yan Li, Asper Childers, Ken Itoh, Masayuki Yamamoto, Heather E. Kleiner

Toxicol Lett, vol. 185, 2009 Mar, pp. 180--186

Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice

Takumi Satoh, Nobuhiko Harada, Tomonori Hosoya, Koujiro Tohyama, Masayuki Yamamoto, Ken Itoh

Biochem Biophys Res Commun, vol. 380, 2009 Mar, pp. 298--302

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice

Keigyou Yoh, Aki Hirayama, Kazusa Ishizaki, Akiko Yamada, Masayoshi Takeuchi, Sho-ichi Yamagishi, Naoki Morito, Takako Nakano, Masami Ojima, Homare Shimohata, Ken Itoh, Satoru Takahashi, Masayuki Yamamoto

Genes Cells, vol. 13, 2008 Nov, pp. 1159--1170

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

Atsushi Maruyama, Saho Tsukamoto, Keizo Nishikawa, Aruto Yoshida, Nobuhiko Harada, Kiyoto Motojima, Tetsuro Ishii, Akio Nakane, Masayuki Yamamoto, Ken Itoh

Arch Biochem Biophys, vol. 477, 2008 Sep, pp. 139--145

Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice

Yasuhiro Kawachi, Xuezhu Xu, Shiroma Taguchi, Hideko Sakurai, Yasuhiro Nakamura, Yoshiyuki Ishii, Yasuhiro Fujisawa, Junichi Furuta, Takenori Takahashi, Ken Itoh, Masayuki Yamamoto, Fumikazu Yamazaki, Fujio Otsuka

J Invest Dermatol, vol. 128, 2008 Jul, pp. 1773--1779

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells

Yuri Kusano, Shunsuke Horie, Takahiro Shibata, Hideo Satsu, Makoto Shimizu, Eri Hitomi, Motohiro Nishida, Hitoshi Kurose, Ken Itoh, Akira Kobayashi, Masayuki Yamamoto, Koji Uchida

Biochemistry, vol. 47, 2008 Jun, pp. 6169--6177

Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts

Harumi Harada, Rika Sugimoto, Ayaka Watanabe, Shigeru Taketani, Kosuke Okada, Eiji Warabi, Richard Siow, Ken Itoh, Masayuki Yamamoto, Tetsuro Ishii

Free Radic Res, vol. 42, 2008 Apr, pp. 297--304

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners

Takumi Satoh, Masanori Izumi, Yuki Inukai, Yasutaka Tsutsumi, Naoto Nakayama, Kunio Kosaka, Yosuke Shimojo, Chieko Kitajima, Ken Itoh, Toshio Yokoi, Takuji Shirasawa

Neurosci Lett, vol. 434, 2008 Apr, pp. 260--265

Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein

Larry G. Higgins, Christophe Cavin, Ken Itoh, Masayuki Yamamoto, John D. Hayes

Toxicol Appl Pharmacol, vol. 226, 2008 Feb, pp. 328--337

A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate

Keita Kanki, Takashi Umemura, Yasuki Kitamura, Yuji Ishii, Yuichi Kuroiwa, Yukio Kodama, Ken Itoh, Masayuki Yamamoto, Akiyoshi Nishikawa, Masao Hirose

Toxicol Pathol, vol. 36, 2008 Feb, pp. 353--361

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

Takumi Satoh, Kunio Kosaka, Ken Itoh, Akira Kobayashi, Masayuki Yamamoto, Yosuke Shimojo, Chieko Kitajima, Jiankun Cui, Joshua Kamins, Shu-ichi Okamoto, Masanori Izumi, Takuji Shirasawa, Stuart A. Lipton

J Neurochem, vol. 104, 2008 Feb, pp. 1116--1131

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis

Katsuyuki Iida, Ken Itoh, Jonathan M. Maher, Yoshito Kumagai, Ryoichi Oyasu, Yukio Mori, Toru Shimazui, Hideyuki Akaza, Masayuki Yamamoto

Carcinogenesis, vol. 28, 2007 Nov, pp. 2398--2403

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer

Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto

J Biol Chem, vol. 282, 2007 Nov, pp. 33681--33690

Subcellular localization and cytoplasmic complex status of endogenous Keap1

Yoriko Watai, Akira Kobayashi, Hiroko Nagase, Mio Mizukami, Justina McEvoy, Jeffrey D. Singer, Ken Itoh, Masayuki Yamamoto

Genes Cells, vol. 12, 2007 Oct, pp. 1163--1178

Double-stranded RNA induces galectin-9 in vascular endothelial cells: involvement of TLR3, PI3K, and IRF3 pathway

Tadaatsu Imaizumi, Hidemi Yoshida, Nozomu Nishi, Hiroshi Sashinami, Takanori Nakamura, Mitsuomi Hirashima, Chikara Ohyama, Ken Itoh, Kei Satoh

Glycobiology, vol. 17, 2007 Jul, pp. 12C--5C

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Jianyong Zhang, Tomonori Hosoya, Atsushi Maruyama, Keizo Nishikawa, Jonathan M. Maher, Tsutomu Ohta, Hozumi Motohashi, Akiyoshi Fukamizu, Shigeki Shibahara, Ken Itoh, Masayuki Yamamoto

Biochem J, vol. 404, 2007 Jun, pp. 459--466

Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline

Yasuki Kitamura, Takashi Umemura, Keita Kanki, Yukio Kodama, Sachiko Kitamoto, Koichi Saito, Ken Itoh, Masayuki Yamamoto, Toshiaki Masegi, Akiyoshi Nishikawa, Masao Hirose

Cancer Sci, vol. 98, 2007 Jan, pp. 19--24

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species

Eiji Warabi, Wakako Takabe, Takashi Minami, Kenji Inoue, Ken Itoh, Masayuki Yamamoto, Tetsuro Ishii, Tatsuhiko Kodama, Noriko Noguchi

Free Radic Biol Med, vol. 42, 2007 Jan, pp. 260--269

BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress

Jianyong Zhang, Tsutomu Ohta, Atsushi Maruyama, Tomonori Hosoya, Keizo Nishikawa, Jonathan M. Maher, Shigeki Shibahara, Ken Itoh, Masayuki Yamamoto

Mol Cell Biol, vol. 26, 2006 Nov, pp. 7942--7952

Ebselen, a seleno-organic antioxidant, as an electrophile

Toyo Sakurai, Masaya Kanayama, Takahiro Shibata, Ken Itoh, Akira Kobayashi, Masayuki Yamamoto, Koji Uchida

Chem Res Toxicol, vol. 19, 2006 Sep, pp. 1196--1204

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex

Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes

J Biol Chem, vol. 281, 2006 Aug, pp. 24756--24768

Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress

Hong Zhu, Li Zhang, Ken Itoh, Masayuki Yamamoto, David Ross, Michael A. Trush, Jay L. Zweier, Yunbo Li

Free Radic Biol Med, vol. 41, 2006 Jul, pp. 132--143

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

Kit I. Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto

Mol Cell Biol, vol. 26, 2006 Apr, pp. 2887--2900